To investigate the effect of storage period and temperature of thawed fresh frozen plasma (FFP) on coagulation factors, Factor Ⅰ, Ⅱ, Ⅴ and Ⅷ levels were measured in 10 units of FFP immediately on thawing and thereafter at 6hrs, 24hrs, 48hrs,
72hrs
stored at 1-6℃ and at room temperature.
The Factor Ⅰ and Ⅱ level stored at 1-6℃ as well as those of at room temperature remained stable from Ohr to 72hrs.
When stored at 1-6℃, the Factor Ⅴ and Ⅷ activity level decreased to 80% of the original activity within 6hrs, but the drop between 6 and 24hrs was 16% in Factor Ⅴ and 13% in Factor Ⅷ.
On the other hand, stored at room temperature, Factor Ⅴ activity level decreased to 88%, and the Factor Ⅷ activity level decreased to 79% of the original activity within 6hrs. The drop between 6 and 24hrs was 55% in Factor Ⅴ, 13% in Factor Ⅷ.
Thereafter the two coagulation factors dropped greatly. Therefore, the storage of thawed FFP at 1-6℃ might be extended to 24hrs when this blood product is used for Factor Ⅴ and Ⅷ content, and to 72hrs for Factor Ⅰ and Ⅱ content.
Once, thawed FFP is exposed to room temperature, the recommended storage period might be up to 6hrs when this blood product is used for Factor Ⅴ and Ⅷ content, and may be extended to 72hrs for Factor Ⅰ and Ⅱ content.
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